Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

1.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.0K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

504
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
504
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

132
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
132
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

532
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
532
What are Lipids?01:38

What are Lipids?

195.5K
Overview
195.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Type 2 Myocardial Infarction: Do We Need Risk Scores?

Journal of the American College of Cardiology·2023
Same author

Accuracy and Clinical Impact of Estimating Low-Density Lipoprotein-Cholesterol at High and Low Levels by Different Equations.

Biomedicines·2022
Same author

Artificial intelligence-augmented electrocardiography for left ventricular systolic dysfunction in patients undergoing high-sensitivity cardiac troponin T.

European heart journal. Acute cardiovascular care·2022
Same author

Measuring copeptin, a surrogate for vasopressin in patients with hypertension - Can it identify those who are volume Responsive?

Clinical biochemistry·2022
Same author

Implementation of High-Sensitivity Cardiac Troponin Assays in the United States.

Journal of the American College of Cardiology·2022
Same author

The retirement of CKMB.

European heart journal. Acute cardiovascular care·2022

相关实验视频

Updated: Jun 6, 2025

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.0K

脂蛋白 (a):未被认可的风险与有前途的未来.

Matteo Manzato1, R Scott Wright1, Allan S Jaffe1,2

  • 1Department of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

Reviews in cardiovascular medicine
|December 2, 2024
PubMed
概括

脂蛋白a (Lp(a)) 是一种心血管风险生物标志物. 针对Lp(a) 的新疗法正在开发中,包括基因沉默和小分子,以解决未满足的临床需求.

科学领域:

  • 心血管医学 心血管医学
  • 脂质学 脂质学是指脂质学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 脂蛋白a (Lp(a)) 是一种关键的脂质生物标志物,与独立的心血管风险相关.
  • 升高的Lp (a) 水平需要针对性治疗策略,以预防初级和二级心血管疾病.
  • 目前的降脂疗法往往无法影响Lp(a) 或甚至可以增加其水平,突出治疗的差距.

研究的目的:

  • 审查升高Lp的病理生理学和临床影响.
  • 专注于针对Lp的新兴治疗策略.
  • 总结一下新型Lp(a) 药物的临床试验的现状.

主要方法:

  • 关于Lp的文献综述 (a) 病理生理学,临床意义和治疗干预措施.
  • 对新型Lp(a) 降低剂的当前和正在进行的临床试验的分析.
  • 评估影响Lp (a) 水平的现有和正在研究的药物类别.

主要成果:

  • 像他类药物这样的现有疗法可能会增加Lp(a),而尼亚和雌激素存在安全问题.
  • 较新的药物,如PCSK9抑制剂和Inclisiran,在降低Lp (a) 方面表现有前途,但需要更多的临床数据.
  • 一些新的治疗方法,包括反意义寡核酸,小干扰RNA和小分子,正在积极临床研究中.
关键词:
在ASCVD的风险.基因干扰疗法 基因干扰疗法脂蛋白 (a) 是一种蛋白质.

更多相关视频

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.2K
Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

404

相关实验视频

Last Updated: Jun 6, 2025

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.0K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.2K
Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

404

结论:

  • 对于直接向和降低Lp (a) 的疗法,以减轻心血管风险,有极大的需求.
  • 目前正在进行的临床试验正在评估旨在通过各种机制降低Lp (a) 的创新药物.
  • 开发有效的Lp(a) 降低疗法具有改善心血管结果的巨大潜力.