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Updated: Jun 6, 2025

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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Published on: September 21, 2011

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一种17β基类固醇脱酶10型 (17β-HSD10) 抑制剂的合成和生物特征

Louise F Dow1, Rasangi Pathirage1, Helen E Erickson1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center Omaha Nebraska 68198 USA paul.trippier@unmc.edu.

RSC medicinal chemistry
|December 2, 2024
PubMed
概括

研究人员合成了一种向17β-HSD10的化合物,这种酶与阿尔茨海默病 (AD) 有关. 虽然该化合物对癌细胞具有毒性,但其中间体在保护神经元免受β粉样蛋白的影响方面表现出潜力,为AD药物发现提供了新的途径.

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