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Updated: Jun 6, 2025
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实现2035年的目标:EUbOPEN - 一个公私合作伙伴关系,以启用和解锁生物在开放的空间
Claudia Tredup1,2, Suzanne Ackloo3, Hartmut Beck4
1Institute of Pharmaceutical Chemistry, Goethe University Frankfurt Frankfurt 60438 Germany knapp@pharmchem.uni-frankfurt.de.
RSC medicinal chemistry
|December 2, 2024
概括
通过创建一个大型化学基因组图书馆和100个化学探针,EUbOPEN项目推动了2035年目标的实现. 这些工具有助于发现人类蛋白质的药理调制剂.
科学领域:
- 药物发现和化学生物学
- 蛋白质组学和制药研究.
背景情况:
- 目标2035旨在在2035年之前为大多数人类蛋白质找到类似药物的分子.
- 欧盟开放项目是实现"目标2035"目标的重要贡献者.
研究的目的:
- 总结EUbOPEN项目的对2035年目标的贡献.
- 突出项目在化学生物学和药物发现方面的成果.
主要方法:
- 建立化学基因组图书馆收藏.
- 开发化学探测器和打击到化学.
- 在患者衍生疾病测定中分析化合物.
- 管理和传播项目数据和试剂.
主要成果:
- 一个化学基因组化合物库,覆盖了三分之一的可用药物的蛋白质组.
- 100个化学探针,在患者衍生分析中进行了分析.
- 数以百计的数据集存储在公共存储库中.
- 一个专门的数据资源,用于EUbOPEN的输出.
结论:
- 欧博对"目标2035"倡议作出重大贡献.
- 该项目的成果为加速药物发现提供了宝贵的资源.
- 公私伙伴关系对于推动大规模的药理学研究至关重要.
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