纤维素,FDP和D-Dimer作为性结肠炎疾病严重性的潜在生物标志物:一项回顾性研究
Wan Feng1, Lei Zhu1, Song Zhao1
1Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine), Nanjing, People's Republic of China.
International journal of general medicine
|December 2, 2024
概括
较高的D-二聚体,纤维素/纤维素降解产物 (FDP) 和纤维素 (FIB) 水平表明性结肠炎 (UC) 更严重. 这些标志物显示出评估UC疾病严重程度的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
- 炎症性肠道疾病研究研究
背景情况:
- 性结肠炎 (UC) 是大肠的一个慢性炎症状况.
- 凝血异常越来越多地在患有UC的患者中被识别出来.
研究的目的:
- 调查凝血参数在评估性结肠炎严重程度方面的作用.
- 评估UC患者的D-二聚合物,FDP和FIB等特定标记物.
主要方法:
- 对364名性结肠炎患者 (163名女性,201名男性) 的分析.
- 使用Truelove和Witts标准评估疾病活动.
- 测量纤维素素 (FIB),D-二元,纤维素/纤维素降解产物 (FDP),C反应蛋白 (CRP) 和红细胞沉积率 (ESR).
主要成果:
- 与非严重病例相比,在严重的UC病例中观察到升高的D-二聚合物,FDP和FIB水平.
- D-二元体显示出显著的诊断潜力,AUC为0.852.
- D-二聚和FIB与炎症标志物CRP和ESR显示出正相关性.
结论:
- D-二聚合物,FDP和FIB被确定为确定性结肠炎疾病严重程度的潜在生物标志物.
- 这些标记可能有助于临床决策和UC患者管理.
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