用多能干细胞和体组织模型和扩展器官的趋势和挑战
Jian-Yun Ge1,2,3, Yun Wang4,5, Qi-Lin Li6
1Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, and South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong, China.
PeerJ
|December 2, 2024
概括
器官技术通过模仿人类器官来推进疾病建模和药物测试. 需要进一步发展,以克服扩大生产和再生医学临床转化方面的挑战.
科学领域:
- 生物技术是生物技术.
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 器官技术在疾病建模和药物测试方面面临着局限性.
- 对器官替代品的高需求和长期等待列表需要先进的有机体解决方案.
- 有机器人提供了一个有希望的方法来回顾器官的复杂性在体外.
研究的目的:
- 审查目前有机体开发和应用的现状.
- 突出最近的进展,并确定有机体技术的现有挑战.
- 提供关于有机体研究和翻译的未来方向的见解.
主要方法:
- 从组织衍生或多能干细胞中开发有机体.
- 优化起始细胞,培养系统和遗传修饰.
- 在有机体组成,结构和血管化技术方面的进步.
主要成果:
- 有机体组成已经从单细胞演变为多细胞类型,改善了仿生学.
- 精细的组织结构和血管化的进展是关键的发展.
- 有机动物图谱,自动化种植和生物库的潜力.
结论:
- 仍然存在重大障碍,包括实现本地组织相似性和可扩展性.
- 克服挑战对于将有机体概念验证转化为实际应用至关重要.
- 进步的目标是建立可靠和可扩展的平台,用于药品和再生医学中的有机体生产.
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