性,心理健康,睡眠和吸烟是终身压力和多发性硬化症严重程度之间的途径
Carri S Polick1,2, Hala Darwish3,4, Leonardo Pestillo de Oliveira5
1School of Nursing, Duke University, Durham, NC 27710, USA.
终身压力因素显著影响多发性硬化症 (MS) 的严重程度. 性可能缓解这些影响,而心理健康不佳,睡眠问题和吸烟可能会加剧MS的结果.
科学领域:
- 神经免疫学 神经免疫学
- 心理神经免疫学 心理神经免疫学
- 流行病学 流行病学
背景情况:
- 终身压力因素与多发性硬化症 (MS) 的特征有关,但潜在的机制和对疾病严重性的影响尚不清楚.
- 保护因素,如弹性,可以减轻MS结果的压力影响很少被研究.
研究的目的:
- 调查连接终身压力因素和对累积多发性硬化症的恢复能力的途径.
- 确定压力-MS严重程度关系中的介导因素,包括心理健康,睡眠和吸烟.
主要方法:
- 这是一项针对924名患有多发性硬化症的成年人进行的横截面在线调查.
- 结构方程建模用于分析压力因素对MS严重程度结果 (残疾,复发,疲劳,疼痛) 的直接和间接影响.
- 通过弹性,心理健康 (焦虑,抑郁症),睡眠障碍和吸烟进行调解.
主要成果:
- 终身压力因素与MS严重程度的增加直接相关 (β = 0.27,p < 0.001).
- 性,心理健康,睡眠障碍和吸烟显著介导了压力-MS严重程度的联系.
- 通过这些媒介,压力因素对多发性硬化症严重性的总间接影响很大 (β = 0.45).
结论:
- 这项研究提供了通过压力影响MS疾病负担的途径的证据.
- 恢复力可能会防止压力影响,而心理健康不佳,吸烟和睡眠障碍可能会放大压力影响.
- 鉴定的调解因素可能是早期多式联络干预措施的目标,以改善多发性硬化症的病程.
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