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协同-特里莫克萨诱导的有毒表皮解剖:尼泊尔的一个病例报告

Sandesh Gaire¹, Suchit Thapa Chhetri²

¹Manmohan Cardiothoracic Vascular and Transplant Centre Kathmandu Nepal.

Clinical case reports

|December 2, 2024

概括

一名66岁的男性因co-trimoxazole而经历了严重的史蒂文斯-约翰逊综合征 (SJS). 早期使用皮质类固醇和抗生素治疗有效地控制了药物诱导的皮肤反应.

科学领域:

皮肤病学皮肤病学
药理学药理学是指药理学的学科.
临界护理医学临界护理医学

背景情况:

史蒂文斯-约翰逊综合征 (SJS) 和有毒表皮解体 (TEN) 是严重的,危及生命的粘膜皮肤反应.
这些情况经常是药物诱导的,涉及水泡形成和广泛的上皮质脱落.
及时诊断和管理对于患者的治疗结果至关重要.

研究的目的:

报告一种由co-trimoxazole诱导的史蒂文斯-约翰逊综合征病例.
突出使用皮质类固醇和宽谱抗生素早期干预的有效性.
强调多学科方法在管理严重皮肤药物不良反应方面的重要性.

主要方法:

一名66岁的男性出现了2天的液体充满病变史.
身体检查显示了广泛的侵蚀,囊泡和囊,涉及60% - 70%的身体表面积.
证实了co-trimoxazole诱导的SJS的诊断,并将患者送入ICU.

主要成果:

患者接受了使用德克萨米他,皮,伊米和阿齐思罗米的治疗.
皮质类固醇和宽谱抗生素在管理SJS方面被证明是有效的.
患者的病情得到了成功的管理,预防了并发症和二次感染.

结论:

三沙可以诱导严重的史蒂文斯-约翰逊综合征.
结合皮质类固醇和广泛抗生素的早期治疗对于SJS/TEN.是有效的.
多学科的方法对于管理严重的皮肤药物不良反应和预防并发症至关重要.

关键词:

在HLA-B*38:02等位基因中.史蒂文斯 - 约翰逊综合征药物不良反应药物不良反应同-特里莫克萨尔有毒的表皮解.

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