在乳腺癌患者的血液学和生物化学参数上的化疗
Tejaswi Pullakanam1, Murugan Mannangatti1, Alamuri Ramesh2
1Department of Biochemistry, Aarupadai, Veedu Medical College & Hospital, Vinayaka Mission's Research foundation (VMRF-DU), Pondicherry, Tamilnadu, India.
Caspian journal of internal medicine
|December 2, 2024
概括
阿德里亚米/赛托克桑 (AC) 化疗显著改变了乳腺癌患者的抗氧化酶和血液学概况. 这会影响治疗期间身体的氧化剂/抗氧化剂平衡.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 化疗虽然向癌细胞,但可以伤害健康细胞.
- 阿德里亚米辛/赛托克桑 (AC) 是乳腺癌常见的化疗方案.
- 了解化疗对身体系统的影响对于患者护理至关重要.
研究的目的:
- 评估AC化疗对乳腺癌患者抗氧化酶和血液病理学特征的影响.
- 评估与这些标志物相关的对诊断和预后的潜在影响.
主要方法:
- 对40名接受AC化疗的乳腺癌患者进行前性研究.
- 血清样本采集在治疗前,治疗中期和治疗后.
- 用于测量抗氧化酶 (MDA,NO,TAS,CAT,GPx,GR,SOD,GST) 的光谱相.
- 血液学参数和临床数据被记录并使用Paired-t测试进行分析.
主要成果:
- 在AC化疗后的抗氧化酶和血液学参数的平均值显著下降.
- 显示减少的特定酶包括MDA,NO,TAS,CAT,GPx,GR,SOD和GST.
- 观察到的变化具有统计学意义 (p < 0.05).
结论:
- 抗氧化化学疗法对乳腺癌患者的氧化剂/抗氧化剂系统有深远的影响.
- 化疗显著改变抗氧化酶活性和减少水平.
- 这些变化可能会对乳腺癌患者的预后和治疗产生影响.
相关概念视频
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K


