性结肠炎水平与性结肠炎活动指标的关联
Yelena Laryushina1, Nadezhda Samoilova-Bedych2, Lyudmila Turgunova2
1Department of Internal Diseases; NCJSC, Karaganda Medical University, Karaganda, Kazakhstan.
与健康人相比,性结肠炎 (UC) 患者的三甲基胺-N-氧化物 (TMAO) 水平明显较低. 较低的TMAO度与UC疾病活性增加相关,表明其作为生物标志物的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 发现生物标志物的发现.
背景情况:
- 性结肠炎 (UC) 的诊断依赖于有限的生物标志物.
- 三甲基胺-N-氧化物 (TMAO) 是一种与UC病变相关的微生物代谢物.
- 调查TMAO与UC临床,实验室和内镜指标的关联至关重要.
研究的目的:
- 评估三甲基胺-N-氧化物 (TMAO) 水平与性结肠炎 (UC) 活性指标之间的关联.
- 为了比较UC患者和健康对照者的TMAO度.
- 探索TMAO与临床,实验室和内镜疾病标志物的相关性.
主要方法:
- 进行了一项观察性,横截面的比较研究.
- 使用高性能液态染色学测量TMAO度.
- 包括63名UC患者和38名健康人群.
主要成果:
- 在UC患者 (0.286μmol/l) 中,TMAO水平明显低于对照组 (0.646μmol/l).
- 在临床活跃和非活跃UC (P=0.003) 之间,TMAO水平有显著差异.
- 与疾病活性相关的TMAO (蒙特利尔尺度,Truelove-Witts),年龄,便频率,WBC,白蛋白和便calprotectin.
结论:
- 与健康个体相比,UC患者的TMAO水平下降.
- 根据UC疾病的活性,TMAO水平会有所不同.
- TMAO显示出作为UC及其严重程度的生物标志物的潜力.
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