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在PERSIAN Guilan队列研究中肝酶升高和糖尿病

Mohammad Taghi Ashoobi¹, Farahnaz Joukar², Kourosh Mojtahedi²

¹Department of Surgery, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Caspian journal of internal medicine

|December 2, 2024

概括

肝酶如ALT,AST,GT和ALP的升高与患上糖尿病 (DM) 的可能性更高有关. 这种关联随着多种酶的升高而加强,突出显示肝脏健康状况.

科学领域:

内分泌学在内分泌学.
肝病学肝病学是一种肝病学.
流行病学流行病学

背景情况:

糖尿病 (DM) 是一个重要的全球健康问题.
有限的研究存在于肝酶和DM之间的关系.
伊朗前性流行病学研究研究 (PERSIAN) 吉兰队列研究 (PGCS) 为这项调查提供了宝贵的数据集.

研究的目的:

为了研究肝酶升高与糖尿病之间的关联.
探索特定肝酶 (ALT,AST,ALP,GT) 与糖尿病患病率之间的相关性.
评估多个肝酶升高对PGCS群体糖尿病风险的影响.

主要方法:

一项涉及10519名PGCS参与者的横截面研究.
收集人口统计和临床数据.
评估胺转移酶 (ALT),酸氨转移酶 (AST),性酸酶 (ALP) 和γ-胺转移酶 (GGT) 的水平;使用SPSS版本21进行统计分析.

主要成果:

糖尿病患病率为24.1%,女性 (27.4%) 比男性 (20.2%) 高.
升高的ALT,AST,GT和ALP水平与糖尿病的几率增加有关 (分别是1.27,1.27,1.52,1.46倍).
糖尿病的可能性随着肝酶升高的数量而增加,对于三个或四个异常酶,患糖尿病的可能性增加了1.77倍.

结论:

患有糖尿病的患者表现出明显更高的肝酶水平.
三或四个肝酶的损伤与DM的风险增加正相关.
在治疗糖尿病患者时,应考虑肝脏状况.

关键词:

糖尿病糖尿病糖尿病脱脂血症是什么意思脱脂血症是什么意思肝脏酶肝脏酶肝脏酶流行程度流行程度

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