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牛,绵羊和山羊对抗SARS-CoV-2的幽默免疫反应

Mehrnaz Ardalan¹, Konner Cool¹, Natasha N Gaudreault¹

¹Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

Veterinary and animal science

|December 2, 2024

概括

在美国牛,绵羊和山羊的低百分比中检测到SARS-CoV-2抗体. 进一步监测对于与人类密切接触的动物物种至关重要,以追踪SARS-CoV-2的流行率.

科学领域:

兽医医学兽医医学兽医医学
传染性疾病传染性疾病
动物病学研究动物病学研究

背景情况:

几种动物物种容易感染SARS-CoV-2病毒.
抗体检测对于动物监测至关重要,因为病毒的散发是暂时的.

研究的目的:

评估美国牛,绵羊和山羊中SARS-CoV-2的血清流行率.
评估商业免疫试验对于检测牲畜中的抗体的有用性.

主要方法:

在2019-2022年期间,从691头牛,698头羊和707头山羊收集了血清样本.
两种商业ELISA (sVNT和N-ELISA) 用于检测SARS-CoV-2抗体.
在sVNT阳性样本上进行病毒中和试验 (VNT).

主要成果:

使用sVNT.的血清阳性率在牛中约为1%,在绵羊中为2%,在山羊中为2.5%.
N-ELISA显示了较高的阳性率:在牛和绵羊中约为4%,在山羊中为2.5%.
通过VNT.在sVNT阳性样本中没有检测到中和抗体活性.

结论:

在美国的牛,绵羊和山羊中观察到低SARS-CoV-2血清阳性.
建议在与人类密切互动的动物中持续监测SARS-CoV-2.

关键词:

牛群是牛群,牛群是牛群,牛群是牛群.艾丽莎·伊丽莎·伊丽莎有山羊有山羊有山羊这是SARS-CoV-2病毒.绵羊是一种羊.监督监督监督监督监督监督

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