关于在外科手术期间继续使用布普伦诺芬的回顾性研究
Morgan Lynn Dermody1, Sandra Lemon2, Lisa Kingdon2
1Community Health Network Inc, Anderson, IN, USA.
Hospital pharmacy
|December 2, 2024
概括
针对阿片类药物使用障碍的持续外科期间布普伦诺芬治疗显著减少了对外科期间吗啡毫克相当剂 (MME) 的需求. 继续服用布普伦诺芬的患者在术后需要较少的MME,与停止服用药物的患者相比.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
背景情况:
- 患有阿片类药物使用障碍 (OUD) 的患者的术后疼痛管理存在独特的挑战.
- 指导方针建议在外科手术期间继续使用布普伦诺芬治疗OUD.
- 需要证据来支持这些关于MME要求和疼痛控制的建议.
研究的目的:
- 评估2020年物质滥用和心理健康服务管理局 (SAMHSA) 准则建议.
- 为了比较术后的MME要求,继续治疗的患者与在外科手术期间停止服用布普伦诺芬的患者.
- 评估这些患者群体的疼痛评分和安全结果.
主要方法:
- 在80名接受布普伦诺芬手术住院患者的多中心回顾性图表审查中.
- 从2015年1月到2022年10月收集的数据.
- 主要结局:MME在术后的前24小时;次要结局:MME在48/72小时,疼痛得分,呼吸抑制和死亡率.
主要成果:
- 继续服用布普伦诺芬的患者在前24小时内需要显著减少MME (23.25对93.38MME;P<.001).
- 在继续治疗组中,在术后48小时和72小时观察到显著较低的MME要求.
- 在继续服用布普伦诺芬的患者中,在48小时和72小时报告了较低的平均疼痛得分.
结论:
- 在外科手术期间继续服用布普伦诺芬与减少MME利用率有关.
- 在外科手术期间继续使用布普伦诺芬可能会导致更好的疼痛管理.
- 这些发现支持当前的指导方针,建议OUD患者在外科手术期间继续服用布普伦诺芬.
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