评估SAME-TT2R2评分对不同族裔人口抗凝血控制不良的预测值
Sahimi Mohamed1, Nik Najibah Nik Abdul Rahman1, Jun Yuan Tan1
1Pharmacy Department, Hospital Sultan Idris Shah, Serdang, Selangor, Malaysia.
Hospital pharmacy
|December 2, 2024
概括
SAMe-TT2R2得分有助于预测马来西亚心房动患者的华法林控制不佳. 超过5的分数表明风险较高,尽管需要进一步的因素来实现最佳管理.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 由于成本效益,华法林仍然是亚洲非膜心房动的常见中风预防方法.
- 非维生素K对抗剂口服抗凝剂 (NOAC) 是替代品,但华法林的负担能力仍然存在.
- 需要一个经过验证的工具来预测不同人群中的华法林抗凝控制.
研究的目的:
- 为了验证SAME-TT2R2得分用于预测马来西亚队列中的抗凝控制不良.
- 评估得分在识别可能在治疗范围 (TTR) 中实现次优时间的患者中的实用性.
- 建立马来西亚非膜心房动患者华法林管理的可靠预测指标.
主要方法:
- 一项回顾性队列研究,涉及49个马来西亚医院的957名患者.
- 治疗范围中的时间 (TTR) <65%,定义为缺乏抗凝控制,使用Roseendaal方法计算.
- 用单变量和多变量分析对TTR进行SAME-TT2R2得分的验证.
主要成果:
- 平均TTR为65.2% (±24),平均SAME-TT2R2得分为5.5 (±0.9). 在此期间,平均TTR为65.2% (±24),平均SAME-TT2R2得分为5.5.
- SAMe-TT2R2评分>5被确定为预测抗凝控制不良的最佳切断值 (灵敏度0.49,特异性0.68).
- 多变量分析证实SAME-TT2R2得分是抗凝控制不良的重要预测因素,尽管C-统计值为0.548.
结论:
- SAMe-TT2R2得分对于评估马来西亚患者的抗凝血控制具有重要意义,得分>5表明风险增加.
- 评分的预测能力有限,需要谨慎解释和考虑其他临床因素.
- 个性化监测和管理策略对于优化华法林治疗结果在这个人群中至关重要.
相关概念视频
Comparing Experimental Results: Student's t-Test
1.5K
The t-test is a statistical method used to compare the sample mean with a population mean or compare two means from two data sets. The test statistic is calculated from the standard deviation, mean, and number of measurements in the data set at a selected confidence interval and then compared to a table of critical values at this confidence level. If the test statistic is smaller than the critical value, the null hypothesis is accepted. In this case, we state that the difference between the...
1.5K
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Statistical Methods to Analyze Parametric Data: Student t-Test and Goodness-of-Fit Test
1.6K
In parametric statistics, two fundamental tests stand out for their utility and wide application: the Student's t-test and goodness-of-fit tests. These tests provide researchers with a robust method for drawing insights from data, testing hypotheses, and making informed decisions based on their findings.
The Student's t-test is a statistical test that examines if there is a statistically significant difference between the means of two groups. This test is instrumental when dealing with...
The Student's t-test is a statistical test that examines if there is a statistically significant difference between the means of two groups. This test is instrumental when dealing with...
1.6K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
616
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
616
Kendall's Tau Test
590
Kendall's tau test, also known as the Kendall rank coefficient test, is a nonparametric method for assessing association between two variables. This test is particularly useful for identifying significant correlations when the distributions of the sample and population are unknown. Developed in 1938 by the British statistician Sir Maurice George Kendall, the tau coefficient (denoted as τ) serves as a rank correlation coefficient, with values ranging from -1 to +1.
A τ value...
A τ value...
590
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
120
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
120


