主体遗传变异及其对伊朗人口HBV和HCV感染的影响:综合系统性审查
Asma Khorshid Shamshiri1, Forouzan Amerizadeh2,3, Zahra Nasrpour Navaei1
1Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Iranian journal of public health
|December 2, 2024
概括
宿主遗传变异影响伊朗B型肝炎 (HBV) 和C型肝炎 (HCV) 感染的风险. 免疫因子基因多态性,特别是在白内素中,与对这些病毒性肝炎感染的易感性有关.
科学领域:
- 遗传学和免疫学 遗传学和免疫学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 肝炎病毒感染 (HBV,HCV) 是全球重要的健康问题,导致肝硬化和肝癌.
- 新出现的证据表明,宿主遗传变异与对病毒性肝炎的易感性之间存在联系.
- 了解这些遗传联系对于伊朗的公共卫生战略至关重要.
研究的目的:
- 综合审查有关宿主基因组变异及其对伊朗人口病毒性肝炎风险的影响现有研究.
- 确定与伊朗HBV和HCV易感性相关的特定基因,多态和分子途径.
主要方法:
- 按照PRISMA指导方针,对到2023年6月发表的波斯语和英语病例控制研究进行系统审查.
- 独立审查两位作者的文章,由第三位作者达成最终共识.
- 利用基因本体学 (GO) 和STRING数据库进行途径和蛋白质相互作用分析.
主要成果:
- 包括70项研究,其中53项专注于单核酸多态 (SNP) 和HBV风险.
- 确定了25个基因和44个SNP,其中瘤坏死因子α,介质蛋白28B和介质蛋白10经常被研究.
- 编码免疫因子,细胞因子,白细胞因子及其受体的基因多态性普遍存在,特别是在白细胞因子家族中.
结论:
- 免疫相关基因 (细胞因子,白内素,受体) 的遗传多态性与伊朗人的HBV和HCV感染风险有关.
- 细胞外和细胞内信号通路在确定对这些病毒性肝炎感染的易感性方面发挥着重要作用.
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