肠道微生物群的改变和与营养的关联在患有乳症的儿童中
Yasemin Ertaş Öztürk1, Efsun Karabudak2, Ödül Eğritaş Gürkan3
1Department of Nutrition and Dietetics, Faculty of Health Sciences Ondokuz Mayıs University Samsun Türkiye.
Food science & nutrition
|December 2, 2024
概括
无质饮食 (GFD) 显著改变了患有腹腔疾病 (CD) 的儿童的肠道微生物群. 这些微生物群变化,包括细菌丰度的变化,发生在六个月内,与营养摄入有关,影响CD的发展.
科学领域:
- 胃肠道学和微生物学
- 儿科健康 儿科健康
- 营养科学 营养科学
背景情况:
- 乳病 (CD) 是一种慢性炎症状况,与肠道微生物组的联系尚不完全理解.
- 饮食干预措施,特别是无质饮食 (GFD),是CD的主要管理策略.
- 了解GFD对儿科微生物群的影响对于管理CD至关重要.
研究的目的:
- 为了研究GFD后患有CD的儿童肠道微生物群的变化.
- 探索GFD的儿科CD患者的营养摄入量和微生物组成之间的关系.
- 评估6个月期间这些变化的时间动态.
主要方法:
- 在6个月内对11名新诊断的儿科CD患者 (3-12岁) 的便样本进行16srRNA测序.
- 使用NDMS,t-test和转移数据分析微生物多样性 (α和β多样性) 和组成.
- 监测饮食摄入量,包括食物消耗和营养水平,以及血清学参数.
主要成果:
- 观察到微生物群落结构的显著变化,在GFD之前,Unifrac距离 (加权和未加权) 更高.
- 在GFD后发现了 *Bacteroides ovatus* 的丰度增加和未分类的 *Lachnospiraceae*, *Paeniclostridium*, *Paraclostridium Peptostreptococcus* 和 *Dielma* 的丰度减少.
- 在*Bifidobacterium* (包括*B. adolescentis*) 和GFD后的脂肪摄入量之间发现了不良关联,表明营养物质与微生物群的相互作用.
结论:
- 六个月的无质饮食显著改变了患有乳症的儿童的肠道微生物群组成.
- 特定的细菌种群的丰富变化,表明在CD病变发生过程中发挥了作用.
- 饮食修改,特别是营养摄入量,可以影响儿科CD的肠道微生物格局.
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