老年妇女的系统性免疫炎症指数和CA125之间的关联:来自横截面NHANES研究的见解
Ling Gao1, Fengyun Xu1, Suli Zhen1
1Department of Gynecology and Obstetrics, Jinjiang Hospital Traditional Chinese Medicine, Jinjiang, Fujian, 362200, People's Republic of China.
International journal of women's health
|December 2, 2024
概括
系统性免疫炎症指数 (SII) 与绝经后妇女的碳水化合物抗原125 (CA125) 有正相关. 这一发现表明,在老年女性中,炎症与这种瘤标志物之间存在潜在的联系.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 系统性免疫炎症指数 (SII) 是一种与各种疾病相关的新兴生物标志物.
- 碳水化合物抗原125 (CA125) 是一种常规的瘤标记物.
- 绝经后妇女SII和CA125之间的关系尚未得到充分证实.
研究的目的:
- 调查绝经后妇女SII和CA125之间的关联.
- 探索这种关联的潜在改变因素.
主要方法:
- 使用从绝经后妇女的NHANES数据进行横截面研究.
- SII计算为:血小板计数 × 中性粒细胞计数/淋巴细胞计数.
- 进行了多变量回归和光滑曲线分析.
主要成果:
- 在SII和CA125水平之间发现了显著的正相关性 (β = 0.01; p = 0.0128).
- 亚组分析表明,与年龄,初潮/绝经年龄或激素替代疗法的相关性没有显著的变化.
结论:
- 在绝经后妇女中,SII和CA125之间存在正相关性.
- 这种关联在不同的人口学子组中似乎是一致的.
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