抗压力影响心理健康:脑肠微生物群相互作用的证据
Eric An1,2, Desiree R Delgadillo3,4,1,5,2, Jennifer Yang3,4,1,2
1David Geffen School of Medicine at UCLA.
Nature. Mental health
|December 2, 2024
概括
大脑 - 肠道 - 微生物系统显著影响心理健康和弹性. 特定的微生物组功能和肠道代谢物是心理健康和恢复力的关键指标.
科学领域:
- 神经科学是一个神经科学.
- 微生物组研究的研究.
- 精神病学是一个精神病学.
背景情况:
- 大脑-肠道-微生物组 (BGM) 系统越来越多地被认为对心理健康的作用.
- 了解心理性的生物学基础对于开发有针对性的干预措施至关重要.
研究的目的:
- 描述与高弹性表型相关的脑肠微生物组 (BGM) 模式.
- 研究微生物组功能,代谢物,神经活动和心理症状之间的关系.
主要方法:
- 用便样本和多式磁共振成像 (MRI) 来分析BGM模式.
- 使用潜伏组件的数据整合分析被用来识别与弹性相关的签名.
主要成果:
- 高弹性与特定的细菌转录组 (环境适应,能量代谢,抗炎),增加的代谢物 (N-乙谷氨酸,二甲基甘氨酸) 和独特的皮层特征有关.
- 神经相关物包括奖励回路中的连接性增加和情绪调节网络中的灰质减少.
- 细菌转录组在分类弹性表型方面表现出最高的准确性.
结论:
- 涉及BGM系统的多原子签名支持心理性,影响情绪调节和认知功能.
- 微生物组功能,支持欧生菌和肠道屏障完整性,对于弹性至关重要.
- 微生物组的修改有可能优化心理健康.
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