人类急性传染病中的细胞衰老:系统性审查
William C Miller1,2, Stephanie Wallace1, William Kamm1
1University of Minnesota Medical School, Minneapolis, MN, United States.
Frontiers in aging
|December 2, 2024
概括
细胞衰老是一种与年龄相关的炎症过程,与COVID-19等严重急性感染有关. 衰老标记与疾病严重程度相关,并在感染后持续存在,突出了进一步研究的关键领域.
科学领域:
- 老年学是一门学科.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 急性传染病导致住院老年人的死亡率和发病率显著.
- 败血症是一种极端形式的感染,涉及全身炎症和器官损伤.
- 免疫衰老,与年龄相关的免疫系统衰退,使老年人易受感染和更糟糕的结果.
研究的目的:
- 系统地审查细胞衰老与人类急性传染病之间的关系.
- 探索与年龄相关的炎症现象,如细胞衰老,如何影响传染病预后.
主要方法:
- 搜索了Embase,Scopus,科学网,全球指数Medicus,科克莱恩图书馆和临床试验.
- 包括研究测量细胞衰老标志物 (p16,p21,端粒长度,hH2AX,衰老相关β银河酶,SASP) 在感染和非感染的患者.
- 两个独立的审稿人对手稿进行了选,并收集了数据.
主要成果:
- 分析中包括了16篇原创文章.
- 12篇文章集中在SARS-CoV-2上,其他文章集中在巴西莱什马尼亚菌,杆菌和C型肝炎上.
- 细胞衰老标记在SARS-CoV-2,P. falciparum,L. braziliensis和C型肝炎感染中得到了强大的上调.
结论:
- 细胞衰老标记与疾病严重程度相关,并在感染解决后持续数月.
- 目前的文献显示,衰老与急性感染,特别是SARS-CoV-2之间存在很强的联系.
- 研究中的差距包括有限的生物类型,小样本大小和老化标志物的不一致测量方法.
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