怀孕期间母亲过量对新生儿甲状腺功能和12周的神经发育状态的影响
Deepashree K Rao1, Ankur Jindal2, Aashima Dabas1
1Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Journal of the ASEAN Federation of Endocrine Societies
|December 2, 2024
概括
孕妇在怀孕期间过多的可以导致新生儿的临时甲状腺问题. 然而,这种过多的并没有影响婴儿在三个月大时的生长或神经发育.
科学领域:
- 内分泌学 在内分泌学.
- 新生儿健康 新生儿健康
- 公共卫生 公共卫生
背景情况:
- 对于甲状腺激素的产生至关重要.
- 怀孕期间的过量可能会对母亲和胎儿构成风险.
- 母亲的水平可以影响新生儿的甲状腺功能.
研究的目的:
- 为了研究母亲过量对新生儿甲状腺功能的影响.
- 评估母亲过量对婴儿生长和神经发育的影响,直到12周大.
主要方法:
- 对产于尿中度高 (UIC ≥500μg/L) 的母亲产生的新生儿进行前性研究.
- 新生儿甲状腺刺激激素 (TSH) 测量通过脚刺在出生时,2,12周.
- 对母亲的UIC和新生儿的生长和发育进行了监测.
主要成果:
- 25.4%的母亲患有升高的UIC;12.2%的新生儿在出生时显示TSH升高.
- 在新生儿中观察到过渡性超thyrotropinemia,在大多数情况下,TSH水平在12周后正常化.
- 孕产妇的水平与新生儿TSH在2周内存在较弱的相关性 (p=0.037).
- 没有诊断出需要治疗的先天性甲状腺功能低下症.
- 新生儿的生长和发育在3个月的TSH升高和没有TSH升高的婴儿之间是可比的 (p>0.05).
结论:
- 孕妇在怀孕期间和分娩前期过多的可以导致新生儿的过渡性超thyrotropinemia.
- 这种短暂的疾病在3个月大时没有对新生儿生长或神经发育产生不利影响.
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