基于连接性的条状子子区域微观结构变化在偶发性肌缩侧面硬化患者:与运动残疾,认知缺陷和血清生物标志物的关系
Yujing Chen1, Sujuan Sun1, Yan Yun2
1Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Provincial Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital of Shandong University, Jinan, China.
European journal of neurology
|December 2, 2024
概括
多层扩散核磁共振 (MRI) 揭示了与运动和认知障碍相关的肌缩侧面硬化症 (ALS) 患者的显著条纹性微结构损伤. 这种损伤是零星ALS的一个关键特征.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
- 在ALS中,状体的微观结构完整性以前没有使用多扩散MRI进行研究.
- 了解条纹损伤对于ALS进展的洞察至关重要.
研究的目的:
- 在偶发性ALS患者体内以连接性为基础的条状子子区域微结构损伤的研究,使用多扩散MRI.
- 探索纹状损伤,运动残疾,认知缺陷和血清生物标志物 (NfL) 之间的关联.
主要方法:
- 追溯研究包括79名ALS患者和53名健康对照 (HC).
- 使用多层扩散MRI和神经元定向分散和密度成像 (NODDI) 来测量条状状子区域微结构参数 (NDI,ODI,ISO).
- 概率学路径学将条纹体细分为六个子区域,基于皮质地质地质连接.
主要成果:
- 与HC相比,ALS患者在双边运动和前额纹状子区域的NDI和ODI显着较低,ISO在双边运动和前额纹状子区域较高.
- 在ALS患者中,腹次区域的微观结构损伤与运动残疾,认知缺陷和血清NfL水平有显著的相关性.
结论:
- 基于连接性的选择性条纹性亚区域微观结构损伤是零星性ALS的独特特征.
- 状损伤似乎对ALS患者观察到的运动和认知障碍有显著的贡献.
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