在结核病治疗期间进行营养补充以改善临床症状:一项双盲,安慰剂控制的随机化试验
Yang Yang1, Jing Cai1, Xinfang Wang1
1Institute of Nutrition and Health, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao, Shandong, 266021, China. magfood@qdu.edu.cn.
Food & function
|December 2, 2024
概括
在结核病患者中,每日营养套餐改善了胸痛和吐等临床症状. 它还减轻了营养不良,对贫血和低蛋白质血症有好处,尽管液涂抹转化仅在特定的患者群体中加速.
科学领域:
- 临床医学 临床医学
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 营养不良是结核病 (TB) 的常见共患病,对治疗结果产生负面影响.
- 虽然在结核病治疗中使用营养支持,但其有效性的证据有限.
- 这项研究调查了特定营养包对结核病患者康复的影响.
研究的目的:
- 评估每日营养包对肺结核患者治疗反应的影响.
- 评估营养包对结核病患者营养状况的影响.
- 为了确定营养包是否影响唾液涂抹转化率.
主要方法:
- 这是一项双盲,安慰剂控制的随机试验,涉及360名糖尿病或糖尿病前期肺结核患者.
- 参与者接受了每天的营养包 (112千卡,9克蛋白质,微量营养素) 或安慰剂六个月.
- 在整个研究过程中,监测了临床症状,唾液涂抹,胸部CT扫描和营养标志物.
主要成果:
- 与安慰剂相比,营养包显著改善吐和减少胸痛.
- 关键的营养标志物包括血红蛋白,白蛋白和淋巴细胞计数被营养包增加.
- 虽然没有影响液涂抹的整体转换,但该包在没有腔的患者中加速了转换.
结论:
- 每日营养套餐有效改善了临床症状,并缓解了结核病患者的营养不良.
- 这项干预措施在与标准结核病治疗一起治疗贫血和低蛋白血症等并发症方面表现有前途.
- 该研究提供了支持将有针对性的营养支持纳入结核病护理方案的证据.
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