印度新血管与年龄相关的黄斑变性 (nAMD) 治疗brolucizumab的初始经验 - 多中心,现实世界的研究
Deependra Vikram Singh1, Aniruddha Agarwal2,3,4, Anubhav Goyal5
1Retina Department, Vitreo-retinal Services, Eye-Q Superspecialty Eye Hospitals Gurugram, Haryana, India.
Indian journal of ophthalmology
|December 2, 2024
概括
静脉内勃鲁西祖马布注射改善视力和减少视网膜厚度在印度人的眼睛与新血管与年龄相关的黄斑变性 (nAMD). 这种治疗显示出有利的安全性,平均19周的无注射间隔为预产后的协议.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 是导致视力丧失的主要原因.
- 静脉内注射是对nAMD的标准治疗方法.
- 布罗卢齐祖马布是对nAMD的新疗法.
研究的目的:
- 评估布罗卢齐祖马布在印度患有nAMD的患者中的有效性和安全性.
- 为了评估在静脉内注射布罗卢齐祖马布后的解剖学和视觉结果.
- 为了确定brolucizumab在现实环境中的安全概况.
主要方法:
- 对印度眼睛进行了回顾性,多中心的研究,这些眼睛患有nAMD,并接受了布罗卢齐祖马布治疗.
- 数据收集包括最佳校正的视力敏度 (BCVA),中央子场厚度 (CSFT) 和6个月,12个月和24个月的液体状态.
- 主要结局是BCVA,CSFT的变化以及眼内炎症 (IOI) 的发生率.
主要成果:
- 在所有随访期间 (P < 0.001) 观察到BCVA和CSFT的显著改善.
- 预产产后 (PRN) 协议实现了平均最大的无注射间隔为19.43周.
- 眼内炎症 (IOI) 发生在2.11%的眼睛中,没有报告视力丧失.
结论:
- 在印度的nAMD患者中,静脉内勃鲁西祖马布表现出有利的视觉和解剖结果.
- 布罗卢齐祖马布的安全性概况是可以接受的,IOI率较低.
- PRN治疗方案允许在注射之间延长时间间隔.
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