增强类似酶的活动通过原子化用于瘤微环境响应级联疗法
Mengdie Jin1, Zhong Liang1, Yongkang Huang1
1Tianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering & National Institute for Advanced Materials, Nankai University, Tianjin 300350, P. R. China.
Journal of the American Chemical Society
|December 2, 2024
概括
一种新型的单原子纳米酶 (Ce SAs@NC) 显示出增强的瘤特异性和催化活性. 这种纳米酶通过产生活性氧物种和调节免疫微环境来对抗瘤,提供了一个有前途的癌症治疗方法.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 纳米酶的催化效能受到有限的酶活性和特异性的限制.
- 开发具有增强瘤向和多面治疗功能的纳米酶对于有效的癌症治疗至关重要.
研究的目的:
- 为了合成和表征一种新型的单原子纳米酶,它以添加碳 (Ce SAs@NC) 为支.
- 评估Ce SAs@NC在体外和体内增强的类似酶的活动,瘤特异性和治疗潜力.
主要方法:
- 用单原子纳米酶 (Ce SAs@NC) 装载的添加碳的合成.
- 与氧化纳米颗粒相比,对类似过氧化酶和类似催化酶的活动的评估.
- 研究Ce SAs@NC对瘤微环境的影响,包括产生活性氧物种,减轻缺氧和免疫细胞调节.
- 对光热效应和体外/体内抗瘤功效的评估.
主要成果:
- 与CeO2纳米颗粒相比,Ce SAs@NC表现出更高的过氧化酶类和酶类活性.
- 纳米酶有效地将过氧化转化为细胞毒性和超氧化基,缓解瘤缺氧.
- Ce SAs@NC证明了瘤特异性免疫调节,刺激M1巨细胞并抑制瘤增殖.
- 单原子大小,光热影响,酶活性和免疫调节的综合作用导致了显著的体外和体外抗瘤疗效,并减少了副作用.
结论:
- Ce SAs@NC呈现了一个高效的纳米酶平台,具有瘤特异性和强大的多酶类活性.
- 纳米酶产生活性氧物种,减轻缺氧和调节免疫微环境的能力为癌症治疗提供了一个有希望的策略.
- 开发的Ce SAs@NC具有显著的治疗潜力,毒性降低,为基于纳米酶的先进癌症治疗铺平了道路.
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