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Updated: Jun 6, 2025

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Published on: January 14, 2020

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在随机临床试验中使用早期失败标准时存在偏差的风险 随机临床试验与立体急性结果

Meet Panjwani1, Jonathan M Holmes1

  • 1Department of Ophthalmology and Vision Science, University of Arizona - Tucson, Tucson, AZ, USA.

Translational vision science & technology
|December 2, 2024
PubMed
概括

在随机临床试验 (RCT) 中实施早期参与者失败规则显著增加了错误结论的风险. 这些规则应避免在未来的试验设计中,以确保可靠的结果.

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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