人类乳头瘤病毒基因型的归属和整合在高度的阴道内皮质新生病
Yuanming Shen1, Sangsang Tang, Yumei Zhou1
1Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Journal of lower genital tract disease
|December 2, 2024
概括
带有宫病变的高度阴道内皮瘤 (HG-VaIN) 会增加恶性转变的风险. 在这些情况下,HPV16的整合是常见的,突出显示了积极治疗的必要性.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 高度阴道内皮质瘤 (HG-VaIN) 是一种癌前疾病.
- 宫病变可以与HG-VaIN共存,影响疾病的进展.
- 人类乳头瘤病毒 (HPV) 是已知的宫和阴道病变的原因之一.
研究的目的:
- 调查HPV基因型的分布和关联以及它们在HG-VaIN中的整合模式.
- 为了将HPV整合与宫病变的存在和进展相关联.
- 评估HG-VaIN患者具有并存的宫病变的恶性转变风险.
主要方法:
- 在207名HG-VaIN.患者中进行了HPV基因型鉴定.
- 对HG-VaIN和侵入性阴道癌 (IVC) 患者的组织样本进行了HPV整合测序分析.
- 配对的宫病变样本与HG-VaIN和IVC样本一起进行分析.
主要成果:
- 与没有宫病变的HG-VaIN (A组,25%) 相比,与同时存在宫病变的HG-VaIN (B组) 显示HPV整合率明显更高 (51.52%).
- HPV16是最常见的整合基因型 (72.73%).
- 疾病向IVC的进展仅发生在B组中,宫病变的共存是一个独立的风险因素.
结论:
- 与宫病变相关的HG-VaIN具有更高的恶性转变风险.
- 对于患有HG-VaIN和宫病变的患者,需要采取主动和强化治疗策略.
- 在宫病变和HG-VaIN诱导的IVC之间,HPV集成部位的高同质性表明存在一种共同的致病途径.
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