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通过TSPO激活,可以通过BDNF/TrkB信号传递改善母体免疫激活诱导的PV内部神经元缺陷

Ming-Jie Mao¹, Hui-Ling Yu¹, Qing-Zhen Liu²

¹Department of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.

Psychopharmacology

|December 2, 2024

概括

在小鼠中产前免疫激活导致认知缺陷和内部神经元损失. 激活TSPO可以通过BDNF/TrkB信号来逆转这些效应,这表明了治疗点.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
发展生物学发展生物学

背景情况:

产前母亲免疫激活 (MIA) 是精神分裂症的危险因素.
帕尔瓦胺 (PV) 内神经元缺陷与认知障碍有关.
对于MIA对PV内部神经元的影响尚不清楚.

研究的目的:

为了研究MIA和PV内部神经元缺陷在后代之间的关系.
探索MIA诱导的神经发育变化的潜在机制.
评估针对TSPO的治疗潜力.

主要方法:

建立了一个使用脂多糖的MIA小鼠模型.
评估成年男性后代的认知功能和行为.
评估了PV内部神经元,TSPO和BDNF/TrkB信号通路.

主要成果:

MIA引发了认知缺陷,减少了PV和TSPO表达,并降低了theta振荡.
TSPO激活改善了MIA引起的PV内部神经元缺陷和行为异常.
抑制BDNF/TrkB信号阻断了TSPO激活的保护作用.

结论:

TSPO激活可以防止MIA后的神经发育和行为异常.
TSPO的保护作用通过BDNF/TrkB信号通路进行介导.
TSPO代表了MIA相关认知障碍的潜在治疗目标.

关键词:

在BDNF/TrkB信号传递方面.认知障碍认知障碍是一种认知障碍.孕产妇的免疫激活帕尔瓦胺内部神经元精神分裂症是一种精神分裂症.转位蛋白 (TSPO) 是一种转位蛋白.

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