在异常性REM睡眠行为障碍中,自主神经系统功能障碍是同核蛋白病的短期风险
Judith Navarro-Otano1,2, Laura Llansó3,4, Aida Alejaldre3
1Neurology Service, Hospital Clínic, Barcelona, Spain. Jnavarr1@clinic.cat.
Journal of neurology
|December 2, 2024
概括
异常性REM睡眠行为障碍 (iRBD) 通常涉及自主神经系统 (ANS) 功能障碍. 客观的ANS,特别是上腺素,基线功能障碍预测短期进展到像帕金森病这样的同核蛋白病变.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 自主神经科学 自主神经科学
背景情况:
- 异常性REM睡眠行为障碍 (iRBD) 是α-synucleinopathies的一个关键早期迹象.
- 自主神经系统 (ANS) 功能障碍在iRBD患者中越来越被认可.
- 了解ANS的参与可以预测临床进展.
研究的目的:
- 在iRBD中描述主观和客观的ANS功能障碍.
- 评估ANS功能障碍是否预测短期进展到同核蛋白病变.
主要方法:
- 对25名iRBD患者进行前性研究,经过多眠图确认.
- 使用复合自主症状评分 (COMPASS-31) 评估了症状性ANS参与.
- 使用复合自主严重性评分 (CASS) 和心血管自主反射试验评估了客观的ANS功能障碍.
主要成果:
- 七名 (28%) 患者进展为同核蛋白病变 (帕金森病或勒维体痴呆症).
- 基线客观ANS功能障碍 (CASS) 在那些进展 (85.7%) 和那些没有 (38.9%) 的人中更常见.
- 上腺功能障碍,特别是Valsalva IV期超标和压力恢复时间延长的损伤,预测了同核蛋白病变的发展.
结论:
- 症状和亚临床ANS功能障碍在iRBD中普遍存在.
- 上腺系统功能障碍是从iRBD发展同核蛋白病变的显著短期风险因素.
关键词:
自主性的功能障碍.自主功能测试自主功能测试痴呆症与利维体的痴呆症.帕金森病是帕金森氏症的一种疾病.雷姆睡眠行为障碍 雷姆睡眠行为障碍综核蛋白病变 (Synucleinopathy) 是一种同核蛋白病变的疾病.更多相关视频
08:33Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
8.2K
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
5.3K
相关概念视频
REM Sleep Behavior Disorder
145
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
145
Sleep-Wake Cycles
1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.2K
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Narcolepsy
89
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
89
Restless Leg Syndrome and Night Terrors
150
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
150
Parkinson's Disease: Overview
479
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
479
