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衰老对机器人辅助激进前列腺切除术后并发症的影响
Shigeki Koterazawa1,2, Masashi Kubota1, Takayuki Sumiyoshi1
1Department of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan.
International journal of clinical oncology
|December 2, 2024
概括
机器人辅助激进前列腺切除术 (RARP) 对老年前列腺癌患者来说是安全的. 随着年龄的增长,术后并发症的发生率并没有显著增加,即使在80岁及以上的人群中也是如此.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 机器人辅助激进前列腺切除术 (RARP) 对老年患者,特别是80岁及以上患者的安全性仍然是争论的主题.
- 老年人前列腺癌 (PCa) 管理需要仔细考虑手术风险和益处.
研究的目的:
- 调查衰老对RARP后术后并发症率的影响.
- 为了比较不同年龄组的并发症率,包括非常老年患者 (≥80岁).
主要方法:
- 一项回顾性队列研究,涉及8055名在25个机构接受RARP的患者.
- 患者被分为四个年龄组:<70,70-74,75-79岁和≥80岁.
- 用治疗权重的逆概率 (IPTW) 调整的回归分析来比较并发症率,以70岁以下的年龄组作为对照.
主要成果:
- 整体术后并发症发生率在各年龄组中相似:8.8% (<70岁),9.7% (70-74岁),9.6% (75-79岁) 和10.0% (≥80岁).
- 根据IPTW调整的分析显示,随着年龄的增长,整体并发症风险没有显著增加.
- 没有特定的并发症类别 (例如,肠道功能障碍,淋巴细胞,感染) 在最年轻和最年长的年龄组之间显示出显著的风险增加.
结论:
- 机器人辅助激进前列腺切除术 (RARP) 在适当选择的老年患者中显示出良好的安全性.
- 年龄,甚至高达80岁及以上,似乎与RARP后术后并发症风险增加无关.
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