牙周炎是否会触发肝脏的炎症反应,这种反应是否会引起氧化应激?
Kaviyarasi Renu1, Abilash Valsala Gopalakrishnan2, Harishkumar Madhyastha3
1Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, 600077, India. kaviyarasir.sdc@saveetha.com.
Odontology
|December 2, 2024
概括
牙周炎,炎症性牙疾病和肝病共享类似的炎症途径. 这篇评论探讨了口腔病原体如何通过氧化应激和炎症恶化肝损伤.
科学领域:
- 口腔生物学 口腔生物学
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 牙周炎影响10-15%的成年人,以慢性炎症为特征.
- 肝脏疾病,包括药物诱导的肝毒性,通常涉及炎症和氧化应激.
- 慢性炎症和氧化损伤是许多疾病的共同标志.
研究的目的:
- 审查周期性病微生物加剧肝病的机制.
- 阐明氧化损伤在关联牙周炎和肝炎中的作用.
- 突出共享的炎症途径在牙周和全身疾病.
主要方法:
- 文献综述侧重于流行病学和机理学研究.
- 分析反应性氧物种 (ROS) 和氧化 (NO) 在炎症中的作用.
- 检查信号通路,如NF-κB和NLRP3激活.
主要成果:
- 反应性氧物种 (ROS) 调解炎症并激活HSCs,破坏DNA,蛋白质和脂质.
- ROS和NO通过细胞因子 (例如IL-1β,TNF-α) 和化学因子触发炎症反应.
- 流行病学研究表明牙周炎和肝损伤之间存在相关性,与氧化应激有关.
结论:
- 牙周病的微生物可以通过增加的氧化损伤使肝脏疾病恶化.
- 共享的炎症和氧化应激机制将口腔健康和肝脏疾病联系在一起.
- 针对氧化应激可以为这两种情况提供治疗效益.
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