门诊护理中的不良药物事件:一个横截面研究
Joseph M Plasek1,2,3, Mary G Amato4,5, Abigail Salem4,5,6
1Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA, USA. jplasek@mgb.org.
Drug safety
|December 2, 2024
概括
药物不良事件发生在44.2%的门诊患者中,抗感染药物和中枢神经系统药物是常见的原因. 这项研究通过详细说明门诊护理中的ADE患病率和特征,增强了药物监督.
科学领域:
- 药物监督 药物监督 药物监督
- 医疗信息学 医疗信息学
- 临床药理学 临床药理学
背景情况:
- 药物不良事件 (ADEs) 在门诊护理环境中被研究不足.
- 电子健康记录 (EHR) 为在门诊患者群体中调查ADE提供了宝贵的资源.
- 了解ADE患病率对于改善非医院环境中的患者安全至关重要.
研究的目的:
- 在门诊环境中估计患病率和描述药物不良事件 (ADEs).
- 利用电子健康记录 (EHR) 进行全面的ADE分析.
- 为 ambulatory care 的药监策略提供信息.
主要方法:
- 一项采用来自学术医疗中心的EHR数据进行的横截面研究 (2018年10月 - 2019年12月).
- 一个分层采样策略,使用与ADE相关的994国际疾病分类 (ICD-10) 代码.
- 随机抽样和临床笔记的注释,以确定ADEs,其致病原体和严重程度.
主要成果:
- 在3126个分析的笔记中,44.2%记录了现有或可能的ADEs,总计有6308个提及.
- 过敏反应 (14.1%) 和显著的不良反应 (60.4%) 是最常见的.
- 估计的患病率为每100次接触1.97次 (包括可能的ADEs在内,每100次接触2.52次),其中抗感染药物和中枢神经系统药物作为主要致病剂.
结论:
- 这项研究使用ICD-10代码和临床笔记量化了门诊环境中的ADE患病率.
- 通过详细介绍 ambulatory care 中的 ADE 特性,这些发现提升了药物监测.
- 这项研究有助于在门诊环境中更好地检测,监测和预防ADEs.
相关概念视频
Pharmacovigilance
786
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
786
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
48
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
48
Acute Kidney Injury IV: Diagnostic Studies and Prevention
8
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
8
Errors occurring during blood pressure monitoring
610
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
Several factors...
610
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
124
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
124
Factors Affecting Renal Clearance: Renal Impairment
61
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
61


