相关实验视频

Updated: Jun 6, 2025

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
11:24

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Published on: July 3, 2015

11.0K

从放射治疗中取出STING:STING检查点介导辐射抵抗

Michael C Brown, Justin T Low, Michelle L Bowie

    The Journal of clinical investigation
    |December 2, 2024
    PubMed
    概括

    两项新的研究揭示了YTHDF1和血氧酶1 (HO-1) 如何在放射治疗后抑制STING通路,从而阻碍抗瘤免疫力. 阻止这些抑制剂可以增强T细胞反应和瘤控制,这表明了新的治疗策略.

    更多相关视频

    Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells05:18

    Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

    Published on: June 9, 2020

    11.0K
    Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines00:09

    Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

    Published on: August 21, 2019

    7.0K

    相关概念视频

    Biological Effects of Radiation02:59

    Biological Effects of Radiation

    All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
    15.3K
    DNA Damage can Stall the Cell Cycle02:37

    DNA Damage can Stall the Cell Cycle

    In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
    9.0K
    Treatment Resistant Cancers02:56

    Treatment Resistant Cancers

    Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
    3.3K