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Updated: Jun 6, 2025

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与C9orf72结合的富含氨酸的二聚重复加剧了G3BP1的病理相分离

Margot Van Nerom1, Junaid Ahmed1,2, Tamas Lazar1,2

  • 1Structural Biology Brussels, Bio-engineering Department, Vrije Universiteit Brussel, Elsene 1050, Belgium.

Proceedings of the National Academy of Sciences of the United States of America
|December 2, 2024
PubMed
概括

富含氨酸的二聚重复 (R-DPRs) 强烈结合G3BP1,在ALS和FTD中启动压力颗粒的形成. 这种结合导致有毒的蛋白质聚合,突出G3BP1作为一个关键的细胞标.

关键词:
在 G3BP1 中使用.液体液体相分离器 液体相分离器神经退行性疾病是一种神经退行性疾病.重复扩散的疾病重复扩散.压力颗粒是压力颗粒.

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