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嗅觉值测试结果的趋势和帕洛斯米亚患者的嗅觉测试的极限
Masayoshi Tei1, Eri Mori2, Rumi Sekine2
1Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan, wejx9d@hotmail.com.
ORL; journal for oto-rhino-laryngology and its related specialties
|December 2, 2024
概括
帕洛斯米亚影响18%的患者,通常是女性,与创伤或感染有关. 虽然保持了嗅觉值,但主观评估和单方面测试是诊断这种嗅觉障碍的关键.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 嗅觉研究 嗅觉研究
背景情况:
- 由于缺乏标准化测试方法,对帕洛斯米亚的诊断具有挑战性.
- 自我报告的 parosmia 症状往往被低估.
- 这项研究调查了嗅觉值趋势,以了解帕洛斯米亚的流行率和诊断潜力.
研究的目的:
- 为了确定参观嗅觉诊所的患者中帕洛斯米亚的患病率.
- 分析患有和没有帕洛斯米亚的患者的嗅觉值模式.
- 评估目前嗅觉测试方法对帕洛斯米亚的诊断效用.
主要方法:
- 407名患者被分为帕洛斯米亚和非帕洛斯米亚组.
- 嗅觉值 (检测,识别,左右差异) 使用喷流T&T嗅觉计进行测量.
- 分析了患者的特征和嗅觉识别测试.
主要成果:
- 帕洛斯米亚的患病率为18%,女性患病率更高,发病时间更短.
- 较低的平均检测和识别值,以及显著的左右检测差异在帕洛斯米亚组中被观察到.
- 创伤后和感染后的嗅觉功能障碍显示出更高的帕洛斯米亚患病率.
结论:
- 帕洛斯米亚影响18%的患者,更常见的是女性,通常是创伤后或感染后.
- 诊断挑战仍然存在,因为嗅觉值可能被保留,需要主观评估.
- 嗅觉侧面化,由左-右检测值差异表明,可能会影响parosmia;单边封闭测试可以帮助向治疗.
相关概念视频
Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
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