在国际多中心研究中,新血管性玻璃瘤作为视网膜造膜瘤高风险组织病理学的预测者
Guy S Negretti1, Tatiana Ushakova2, Serov Yuri2
1Judith Kingston Retinoblastoma Unit, The Royal London Hospital, London, United Kingdom.
Retina (Philadelphia, Pa.)
|December 2, 2024
概括
视网膜母细胞瘤眼中的新血管玻璃眼 (NVG) 与高风险的组织病理学和转移风险增加有关. 早期发现NVG对于评估视网膜母细胞瘤的结果至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 视网母细胞瘤是儿童中最常见的初级眼内恶性瘤.
- 神经血管玻璃眼 (NVG) 是可在视网膜母细胞瘤中出现的严重并发症.
- 对视网膜母细胞瘤和NVG眼睛的组织病理学和结果的评估对于治疗计划至关重要.
研究的目的:
- 为了评估在视网膜母细胞瘤中初级核化后的组织病理学和患者结果,眼睛呈现新血管玻璃眼 (NVG).
主要方法:
- 一个国际多中心的回顾性病例系列,包括1420名接受视网膜母细胞瘤初级核化治疗的患者.
- 在NVG患者和CT2期患者之间比较了临床特征和病理等级 (美国联合癌症委员会,第8版).
- 高危组织病理被定义为病理阶段≥pT2b.
主要成果:
- 新血管玻璃眼 (NVG) 在16%的患者中存在 (224/1,420).
- NVG与高危组织病理学有显著的关联 (OR 1.77,95% CI:1.23-2.56).
- 与cT2患者相比,NVG患者的转移风险更高 (P=0.04).
结论:
- 呈现时的神经血管大眼是视网膜母细胞瘤中高风险基因病理学的重要指标.
- 存在NVG与转移的风险增加有关.
- 这些发现强调了NVG作为视网膜母细胞瘤管理中的预后因素的重要性.
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