原因,预测或观察? 对不利结果途径的关键事件关系的不同理解及其对实践的影响
Zheng Zhou1, Jeroen L A Pennings2, Ullrika Sahlin1
1Center for Environmental and Climate Science, Lund University, Sweden.
Environmental toxicology and pharmacology
|December 2, 2024
概括
这项研究揭示了在不良结果途径 (AOP) 文档中关键事件关系 (KER) 的术语不一致. 需要仔细考虑因果和预测术语,以便在毒理学中进行更好的跨学科沟通.
科学领域:
- 毒理学 毒理学 毒理学
- 计算毒理学计算毒理学
- 监管科学 监管科学
背景情况:
- 不良结果途径 (AOPs) 框架对于毒理风险评估至关重要.
- 在AOP指南中,关键事件关系 (KER) 的术语变化带来了挑战.
研究的目的:
- 检查AOP文档中因果,观察和预测术语的使用和适应.
- 为了识别AOP术语和实际方法之间的潜在不匹配.
主要方法:
- 进行了文献搜索和AOP指导文件的文本分析.
- 在AOP开发中分析了因果,观察和预测语言的应用.
主要成果:
- 关键事件关系 (KER) 经常使用因果和预测术语来描述.
- 术语适应在AOP开发的不同阶段有所不同.
- 从预测模型中推断因果关系是一个重大挑战.
结论:
- 在AOP指南的术语和实际应用之间存在潜在的断开.
- 清晰,一致的术语对于有毒学有效的跨学科沟通至关重要.
- 将已确定的因果关系纳入定量AOP模型需要进一步开发.
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