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Updated: Jun 21, 2026

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
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用石墨烯近场效应在单个分子水平上观察到的DNA混合动力学

Maria M Soares1, João Freitas1, Tiago Queirós1,2

  • 1INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, Braga 4715-330, Portugal.

The journal of physical chemistry. A
|December 2, 2024
PubMed
概括

这项研究引入了一种基于石墨烯的传感器,用于在杂交过程中跟踪单个DNA针头. 先进的平台揭示了纳米级的展开过程和中间状态,为分子动力学提供了新的见解.

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Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...