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Updated: Jun 6, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
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Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

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结合结合亲和力和强力信号,可以实现合理的CAR设计,用于增强T细胞功能

Markus Barden1, Patrick Ronan Elsenbroich1, Vivian Haas2

  • 1Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany.

Journal for immunotherapy of cancer
|December 2, 2024
PubMed
概括

调整嵌合抗原受体 (CAR) T细胞功能是固体瘤治疗的关键. 受到疏水性相互作用影响的CAR结合亲和和和强化信号,对于持续的T细胞活性和瘤控制至关重要.

关键词:
化学抗原受体 - - CAR免疫治疗是一种免疫疗法.一个T细胞细胞.

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