脂质血:一种客观的非侵入性光度方法,用于分类血度及其与红细胞血解相关性
Lara A E de Laleijne-Liefting1, Ido J Bontekoe1, Johan W Lagerberg1
1Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, the Netherlands.
Vox sanguinis
|December 2, 2024
概括
一种新的光谱光度法客观地测量了血度,与甘油三水平相关联. 这可以预测储存期间红细胞度血液溶解的增加,提高血液产品的安全性.
科学领域:
- 血液银行和输血医疗服务
- 生物物理化学 生物物理化学
- 临床病理学 临床病理学
背景情况:
- 血度是视觉评估,导致主观拒绝单位.
- 脂血性血对红细胞度 (RCC) 质量的影响尚不清楚.
- 视觉检查对于等离子体度是不可靠的.
研究的目的:
- 开发一个对等离子体度的客观光谱法.
- 评估光谱光度数据与血甘油三水平之间的相关性.
- 评估储存期间RCC血液溶解中的血度的预测值.
主要方法:
- 使用光反射参数 (L*,a*,b*) 和甘油三 (TG) 水平,分析了365个血单位的度.
- 存储了6周的脂血全血中减少的RCC.
- 评估RCC质量参数,包括血液溶解.
主要成果:
- 实际上,L*值可以明显区分出杂/脂血性血.
- 在TG水平和L*值之间观察到强烈的相关性 (R2=0.703).
- 血TG≥2.5 mmol/L的L*>50 (90%的特异性/敏感性). 血TG≥2.5 mmol/L的L*>50 (90%的特异性/敏感性).
- 来自血的RCC与L* ≥68显示出显著更高的血液溶解 (p <0.05).
结论:
- 非侵入性光度分析准确地测量了血度,与视觉检查和TG水平相关联.
- 测量L*值可以识别高TG等离子体,预测RCC血液溶解风险增加.
- 这种方法增强了血液储存中的客观评估.
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