[对慢性淋巴细胞白血病患者的COVID-19单中心研究]
1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
|December 2, 2024
概括
慢性淋巴细胞白血病 (CLL) 患者的COVID-19显示出严重感染率高,疫苗接种率低. 渐进性CLL和最近的抗CD20治疗增加了风险,而布鲁顿氨酸激酶 (BTK) 抑制剂单疗提供了保护.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 慢性淋巴细胞白血病 (CLL) 患者在COVID-19大流行期间面临着独特的挑战.
- 了解风险因素和治疗结果对于管理这些双重疾病至关重要.
研究的目的:
- 调查中国的CLL患者的COVID-19疫苗接种情况,临床特征和预后.
- 在CLL患者中识别与严重/危急COVID-19相关的风险因素.
主要方法:
- 在2022年11月至2023年2月期间诊断出COVID-19的328名CLL患者的回顾性分析.
- 使用单变量和多变量逻辑回归分析来识别严重/危急COVID-19的风险因素.
- 到2023年10月的随访数据包括后续感染和抗体标位.
主要成果:
- 23.5%的CLL患者经历了严重/危急的COVID-19.
- 严重的COVID-19的危险因素包括年龄>67,糖尿病,慢性乙型肝炎,进展性CLL和最近的抗CD20抗体治疗.
- 渐进性CLL是一个独立的危险因素,而布鲁顿氨酸激酶 (BTK) 抑制剂单一治疗显示出保护作用.
- 死亡率为2.7%,主要是由于呼吸系统和心力衰竭.
结论:
- 患有CLL的患者的COVID-19疫苗接种率较低,严重感染的发病率很高.
- 渐进性CLL和最近的抗CD20治疗与更糟糕的COVID-19结果有关.
- 单独使用BTK抑制剂治疗可能会改善CLL患者的COVID-19结果.
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