Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Biological applications and future perspectives of bioactive compounds as pig feed additives.

Animal nutrition (Zhongguo xu mu shou yi xue hui)·2026
Same author

From Sunlight to Screens: Modeling When Light Exposure Matters Most for Sleep and Circadian Health.

Clocks & sleep·2026
Same author

CAMK1 Suppresses Anoikis Resistance and Liver Metastasis in Colorectal Cancer.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Energy-precision trade-off in mitotic oscillators revealed by ATP modulation in artificial cells.

bioRxiv : the preprint server for biology·2026
Same author

Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens.

Molecular biology and evolution·2026
Same author

Mechanically-induced Septin Networks Protect Nuclear Integrity.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Jun 6, 2025

In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans
05:11

In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans

Published on: July 12, 2024

335

空间异质性加速了青蛋提取物中的阶段到触发波过渡.

Owen Puls1,2, Daniel Ruiz-Reynés3,4, Franco Tavella2,5

  • 1Department of Physics, University of Michigan, Ann Arbor, MI, 48109, USA.

Nature communications
|December 2, 2024
PubMed
概括

跨越大距离的细胞循环协调是通过一个单一的生物过程实现的,涉及线粒波. 这项研究揭示了从相向触发波的过渡,这对于同步细胞分裂至关重要.

更多相关视频

Two Types of Assays for Detecting Frog Sperm Chemoattraction
10:02

Two Types of Assays for Detecting Frog Sperm Chemoattraction

Published on: December 27, 2011

19.0K
Production of Xenopus tropicalis Egg Extracts to Identify Microtubule-associated RNAs
10:01

Production of Xenopus tropicalis Egg Extracts to Identify Microtubule-associated RNAs

Published on: June 27, 2013

13.7K

相关实验视频

Last Updated: Jun 6, 2025

In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans
05:11

In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans

Published on: July 12, 2024

335
Two Types of Assays for Detecting Frog Sperm Chemoattraction
10:02

Two Types of Assays for Detecting Frog Sperm Chemoattraction

Published on: December 27, 2011

19.0K
Production of Xenopus tropicalis Egg Extracts to Identify Microtubule-associated RNAs
10:01

Production of Xenopus tropicalis Egg Extracts to Identify Microtubule-associated RNAs

Published on: June 27, 2013

13.7K

科学领域:

  • 细胞生物学 细胞生物学
  • 发展生物学 发展生物学
  • 生物物理学的生物物理.

背景情况:

  • 细胞周期进展是由循环素依赖性激酶1 (Cdk1) 活性调节的,呈现周期性振荡.
  • 大型早期胚胎中的同步细胞分裂需要远程协调机制,而不仅仅是简单的扩散.
  • 已经提出了包括相和触发波在内的线性波来解释这种协调,但它们的动态建立尚不清楚.

研究的目的:

  • 研究阶段和触发波在协调细胞周期振荡中的动态建立和关系.
  • 阐明早期胚胎系统中长距离细胞周期同步背后的机制.

主要方法:

  • 使用了Xenopus laevis蛋提取物用于体外实验.
  • 使用Cdk1 Förster共振能量传输 (FRET) 传感器来监测Cdk1活动动态.
  • 整合了数值模拟来建模波浪传播和引流动力学.

主要成果:

  • 在同质的Xenopus蛋提取物中观察到从相波到触发波动态的过渡.
  • 证明空间异质性和核的存在加快了引进过程.
  • 数字模拟表明,相波是更稳定的触发波的短暂前体.

结论:

  • 阶段和触发波代表单个生物过程中的不同但相互连接的阶段,用于长距离细胞周期协调.
  • 过渡动态对于在大型细胞系统中建立同步细胞分裂至关重要.
  • 这项工作为协调细胞周期进展的基于波的机制提供了统一的理解.