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Updated: Jun 6, 2025

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

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在小鼠中,OSGEP通过调节亲胰岛素翻译和维持ER应激稳态来调节岛屿β细胞功能,并维持ER应激稳态

Yujie Liu1,2,3,4,5, Xuechun Yang1,2,3,4, Jian Zhou1,2,3,4

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.

Nature communications
|December 2, 2024
PubMed
概括

酶OSGEP对于岛屿β细胞功能和葡萄糖平衡至关重要,因为它确保了适当的亲胰岛素折叠. 它的缺乏会损害胰岛素活性,导致糖尿病,但OSGEP提供了一个潜在的治疗点.

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