在关节骨折手术后入院高血糖症和术后肺炎之间的相关性:一项倾向性得分匹配研究
Yuanchao Luo1, Xiaomin Ni2, Wei Yao3
1Department of Orthopedics, Zigong First People's Hospital, No. 42, Yizhi Road, Shangyihao Street, Zigong, 643000, Sichuan Province, People's Republic of China.
Scientific reports
|December 2, 2024
概括
住院高血糖症,或到达时高血糖,是老年关节骨折患者手术后肺炎 (POP) 的独立危险因素. 较高的血糖水平与增加的POP风险相关,特别是在非糖尿病人中.
科学领域:
- 老年医学 老年医学
- 内分泌学 在内分泌学.
- 外科手术的结果
背景情况:
- 在部骨折患者的入院高血糖症和术后肺炎 (POP) 之间的联系仍然不清楚.
- 骨折在老年人中很常见,POP是一个显著的并发症.
研究的目的:
- 为了研究入院高血糖症和部骨折手术后POP发生率之间的关联.
- 确定入院高血糖是否是POP的独立风险因素,并探索剂量依赖关系.
主要方法:
- 对1267名接受关节骨折手术的老年患者进行了回顾性分析.
- 根据入院血糖水平分类为正常血糖和高血糖组.
- 多变量逻辑回归和倾向得分匹配 (PSM) 来控制混者.
主要成果:
- 入院高血糖症患者的POP比率显著更高 (13.2%与PSM前的4.8%,PSM后的10.1%与5.8%).
- 入院高血糖是POP的一个独立风险因素 (OR=2.64前PSM,OR=2.90后PSM).
- 观察到剂量-反应关系;高血糖症在非糖尿病患者中比糖尿病患者具有更高的风险.
结论:
- 住院高血糖是老年关节骨折患者POP的独立风险因素.
- 摄入血糖和POP风险之间存在剂量反应关系.
- 过高血糖对POP的影响在非糖尿病患者中更为明显,并受到ASA分类的影响.
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