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早期社会环境对黑猩猩白质的长期影响

Michele M Mulholland¹, Erin Hecht², Michael J Wesley³

¹Department of Comparative Medicine, Michale E Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, 650 Cool Water Dr, Bastrop, TX, 78602, USA. mmmulholland@mdanderson.org.

Scientific reports

|December 2, 2024

概括

早期不利的养殖条件会影响黑猩猩的大脑发育. 使用机器学习的白质分数异构 (FA) 分析几十年后可以区分母养和幼儿园养的黑猩猩.

科学领域:

神经科学是一个神经科学.
灵长类动物学灵长类动物学
发展心理学发展心理学

背景情况:

不利的早期养育条件会对灵长类动物的社会行为,认知和大脑发育产生负面影响.
了解养殖的长期神经影响对于灵长类动物的福利和保护至关重要.

研究的目的:

为了确定白质完整性,通过分数异构度 (FA) 测量,可以追溯区分母养 (MR) 和幼儿园养 (NR) 黑猩猩.
研究养殖条件对黑猩猩白质结构的长期影响.

主要方法:

对MR和NR黑猩猩的档案扩散张力成像 (DTI) 数据的分析.
支持矢量机器学习的应用,以根据白质FA对黑猩猩进行分类.
基于voxel的形态测量,以确定养殖群体之间FA的区域差异.

主要成果:

机器学习成功地根据白质FA对MR和NR黑猩猩进行了分类,准确率为76.32%.
在特定的大脑区域观察到FA的显著差异,包括体和前运动皮质.
在NR黑猩猩的早期社会干预没有完全解释白质错误分类,这表明持久的影响.

结论:

幼儿园养育对黑猩猩的白质结构有持续的,可检测的影响.
虽然早期干预可能有利于灰质,但由于幼儿园养育而导致的白质变化似乎是持久的.
需要对综合干预措施进行进一步的研究,以减轻非人类灵长类动物的长期大脑发育影响.

关键词:

负面的培养负面的培养大脑发育大脑发育黑猩猩是黑猩猩的一种.机器学习是机器学习.白质是白质的组成部分.

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