由于COVID-19和凝固参数的死亡率之间的关联:系统审查和元分析研究研究
Alireza Abdollahi1, Saeed Nateghi2, Zahra Panahi3
1Department of Pathology, School of Medicine, IKHC, Teheran University of Medical Sciences, Tehran, Iran.
BMC infectious diseases
|December 2, 2024
概括
这项研究发现,死去的COVID-19患者的血小板数量较低. 然而,较高的D-Dimer,INR和PT水平与COVID-19死亡风险的增加有关.
科学领域:
- 医学研究 医学研究
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19对全球健康构成重大威胁,凝血病是已知的并发症.
- 了解凝血标志物与COVID-19死亡率之间的关系对于患者管理至关重要.
研究的目的:
- 系统地审查和元分析COVID-19死亡率与关键凝血因子之间的关联.
- 确定特定的实验室标记物,可以预测COVID-19患者的死亡率.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索到2024年10月.
- 包括48项符合PICO元分析标准的研究.
- 用于统计分析的随机效应模型,用I2测试评估异质性.
主要成果:
- 与幸存者相比,非幸存者的血小板数量平均显著下降.
- 两组之间激活的部分血栓形成时间 (aPTT) 或纤维素原水平没有显著差异.
- 在已故患者中,D-Dimer,国际规范化比率 (INR) 和前血红素时间 (PT) 的综合平均水平显著更高.
结论:
- 血小板计数,D-Dimer,INR和PT是COVID-19死亡率的潜在指标.
- D-Dimer,INR和PT水平升高与COVID-19患者死亡风险增加有关.
- 进一步的研究可能会完善这些标记在临床决策中的使用.
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