在怀孕的穆尔西亚-格拉纳达山羊中活体减弱的山羊疫苗接种:剂量影响和结果
Hossein Esmaeili1,2, Mohammadreza Ghorani3, Seyed Mehdi Joghataei4
1Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, P.O.Box: 1419963114, Tehran, Iran. hesmaeli@ut.ac.ir.
BMC veterinary research
|December 2, 2024
概括
标准的山羊疫苗剂量对孕山羊是安全的. 在怀孕的穆尔西亚格拉纳达山羊中,活体减弱山羊疫苗 (GTPV) 的双剂量导致流产和感染,突出了需要精确的疫苗接种方案的需要.
科学领域:
- 兽医病毒学 兽医病毒学
- 畜牧健康管理 畜牧健康管理
- 免疫预防的免疫预防.
背景情况:
- 羊病毒 (GTPV) 对牲畜健康和经济构成重大威胁,特别是在发展中国家.
- 由于最近在以前清除的地区爆发了疫情,有效的控制策略,包括疫苗接种至关重要.
- 该研究侧重于怀孕的穆尔西亚-格拉纳达山羊,这是一种不原产于伊朗的品种,以评估疫苗接种方案.
研究的目的:
- 评估标准与双剂量活体减弱的山羊疫苗在孕山羊的安全性和有效性.
- 确定在易受感染的山羊群中预防GTPV的最佳疫苗接种方案.
主要方法:
- 400只怀孕的穆尔西亚格拉纳达山羊被分为两个组.
- 组A接受标准剂量 (0.5毫升) 的活体减弱型GTPV疫苗.
- B组接受了同一种疫苗的双剂量 (0.9毫升),每天对临床症状和PCR分析进行监测.
主要成果:
- 接受标准剂量的山羊没有出现不良反应或流产.
- 接受双剂量的山羊中有37%经历了流产,并表现出GTPV感染的迹象.
- 分子分析证实疫苗菌株是感染的来源,而不是外部污染.
结论:
- 坚持标准的疫苗剂量对于怀孕的穆尔西亚格拉纳达山羊来说至关重要,以防止堕胎.
- 疫苗接种方案需要修订,以考虑到品种特异性因素,怀孕和疫情条件.
- 定制的疫苗接种策略对于确保不同山羊品种的疫苗安全性和有效性至关重要.
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