阿弗利塞普特高剂量 (8毫克) 相关的眼内炎症 (IOI) - 一系列病例
Laura Hoffmann1, Stephan Michels2, Chiara Eandi3
1Vista Augenklinik Binningen, Hauptstrasse 55, Binningen, 4102, Switzerland.
BMC ophthalmology
|December 2, 2024
概括
一组患者在接受阿弗利塞普特8毫克静脉内注射后出现了急性眼内炎症. 这强调了需要保持警,尽管该药在临床试验中具有良好的安全性.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 在静脉内膜内注射抗VEGF注射后监测炎症事件至关重要,特别是在像aflibercept 8 mg这样的新药时.
- 虽然aflibercept 8 mg在研究中显示出与aflibercept 2 mg相似的安全性,但实际病例报告对于风险评估至关重要.
研究的目的:
- 为了描述一系列患者,在注射8毫克的静脉内阿弗利塞普特后,他们出现了急性眼内炎症 (IOI).
- 为了提高临床意识,关于与aflibercept 8 mg相关的潜在炎症并发症.
主要方法:
- 一个涉及8名患者的病例系列,他们在3个中心内静脉内服8毫克aflibercept后发展了IOI.
- 患者在注射后2至17天内出现炎症;之前的抗VEGF疗法没有发生任何事件.
- 炎症通过局部类固醇和NSAIDs得到缓解,视力恢复良好.
主要成果:
- 一组8名患者在aflibercept 8mg注射后出现了急性眼内炎症 (玻璃体和前腔).
- 没有观察到血管炎,乳头炎或视网膜炎的迹象.
- 用局部类固醇和NSAIDs治疗导致炎症的解决和在11-24天内良好的视力恢复.
结论:
- 报道了一组注射相关的眼部炎症病例,这些病例是由于注射了静脉膜内阿弗利塞普特8毫克后发生的.
- 这种炎症的原因仍然不清楚.
- 临床意识对于检测此类事件至关重要,即使在关键研究中似乎具有低风险概况.
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