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在工程模型中接受性别特异性差异,以增强对功能生物理解
Charlotte Veser1, Aurélie Carlier2, Vanessa Dubois3
1Utrecht Institute for Pharmaceutical Sciences, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands.
Biology of sex differences
|December 2, 2024
概括
本次审查强调了在体模型中将性别作为生物变量纳入关键的需要. 结合性别特征可以提高对男性和女性功能,疾病和药物反应的理解.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 翻译医学是一种翻译医学.
- 药物发现 药物发现 药物发现
背景情况:
- 在体外模型对于研究功能,疾病和药物开发至关重要.
- 现有的体外模型经常忽视基于性别的生物学差异,尽管已知性别之间功能和疾病呈现的差异.
- 这种监督可能会错过性别特异性疾病机制和差异性药物反应.
研究的目的:
- 强调将性别作为人类脏体外模型中的生物变量整合的重要性.
- 记录已知的活动在健康和疾病中的性别特征.
- 提出将基于性别的差异纳入脏体外模型的框架.
主要方法:
- 关于性别特异性生物学现有文献的全面审查.
- 分析功能,疾病机制和药物反应中的基于性别的差异.
- 关于实验性设计标准的建议,用于体外包括性别的脏模型.
主要成果:
- 在脏生理学和病理学方面存在显著的基于性别的差异.
- 目前的体外脏模型缺乏对这些性别特征的充分表现.
- 整合性别特异性的细胞和组织特征对于模型准确性至关重要.
结论:
- 试管婴儿模型必须将性别作为一个基本变量,以准确地反映人类生物学.
- 包括性别在内的模型将有助于更好地了解脏机制,疾病以及药物的有效性/安全性.
- 这种方法支持个性化医疗和患者特定治疗策略的发展.
相关概念视频
01:45Kidney Structure
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...