在生殖年龄妇女的炎症和卵巢功能
Anneliese Long1,2, Anne Z Steiner3, Amanda L Thompson1,2,4
1Department of Anthropology, University of North Carolina, Chapel Hill, North Carolina, USA.
概括
通过C-反应蛋白测量的炎症与早期毛囊阶段的抑制B和毛囊刺激激素水平较低有关. 这表明炎症可能会影响卵巢功能,但不一定会减少卵巢储备.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 妇女健康 妇女健康
背景情况:
- 炎症是免疫激活的标志物,可以影响卵巢和质功能,这对怀孕至关重要.
- 炎症升高可能表明卵巢功能障碍,可能反映在抗穆勒尔激素 (AMH),卵泡刺激激素 (FSH) 和抑制B水平.
研究的目的:
- 调查炎症标志物C反应蛋白 (CRP) 与卵巢功能关键生物标志物 (AMH,FSH,inhibin B) 在早期卵泡期之间的关系.
- 评估炎症是否与卵巢储备减少有关.
主要方法:
- 来自"怀孕时间"前性队列研究 (2008-2016) 的数据的二次分析.
- 包括703名30至44岁的女性试图怀孕,没有不孕史或相关疾病.
- 在月经周期的2-4天内测量血清CRP,AMH,FSH和B抑制剂.
主要成果:
- 20%的CRP增加与抑制B和FSH水平的下降有关.
- 没有发现CRP和AMH之间或卵巢储备减少的几率之间存在显著的关系.
- 一个趋势表明AMH的潜在增加具有更高的CRP,尽管在统计学上并不显著.
结论:
- 通过CRP表示的炎症与卵巢功能的特定生物标志物 (FSH,inhibin B) 在早期的卵泡阶段有关.
- 这些发现表明炎症在调节卵巢功能方面可能发挥作用.
- 在这个队列中,CRP水平与卵巢储备减少没有显著联系.
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