用于预测多重原发性食道状细胞癌的预后的诺莫图
Kexi Wang1, Jian Zhong2, Danting Su3
1Department of Thoracic Surgery, Sun Yat-sen Memorial Hospital, Guangzhou, China.
Annals of medicine
|December 3, 2024
概括
难以预测同步多重初级食道状细胞癌 (SMPESCs) 的存活率. 现在,新的名图可以预测存活结果,并指导这些罕见病例的治疗策略.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 手术瘤学手术瘤学
背景情况:
- 同步多重初级食道状细胞癌 (SMPESCs) 是罕见的,使得生存预测具有挑战性.
- 开发预测工具对于SMPESC患者有效的治疗策略至关重要.
研究的目的:
- 构建用于预测SMPESC患者的生存结果的诺姆图.
- 确定无疾病生存期 (DFS) 和整体生存期 (OS) 的独立预后因素.
- 评估术后辅助治疗对SMPESC淋巴结转移的SMPESC患者的影响.
主要方法:
- 对135名SMPESC患者的临床和生存数据的回顾性分析.
- 单变量和多变量考克斯回归分析以确定预后因素.
- 使用一致性指数和决策曲线分析构建名图和内部验证.
主要成果:
- 年龄,病变部位,淋巴结转移,淋巴结剖析,乳酸脱酶和淋巴细胞对单细胞的比率是DFS和OS的独立预后因素.
- 诺米图显示出良好的预测准确性,一致性指数为0.752 (DFS) 和0.756 (OS).
- 术后辅助疗法显著改善了在淋巴结转移的患者中的OS,但不是DFS.
结论:
- 开发的诺姆图有效预测SMPESC患者的1年,3年和5年的生存结果.
- 辅助疗法可以提高SMPESC患者的整体存活率淋巴结转移.
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