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炎症性肠病和相关的皮肤表现
Usman Ghani1, Mahwish Ahmed2, Athar Nayeem3
1Mohtarma Benazir Bhutto Shaheed Medical College Mirpur-AJK.
Journal of Ayub Medical College, Abbottabad : JAMC
|December 3, 2024
概括
在炎症性肠病 (IBD) 中,皮肤疾病很常见,影响超过30%的患者,特别是那些患有克罗恩病 (CD) 的患者. 活性IBD与更多的皮肤问题相关,而抗TNF治疗可能会减少新的表现.
科学领域:
- 胃肠病学 胃肠病学
- 皮肤病学 皮肤病学
- 临床医学 临床医学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),经常出现皮肤表现.
- 这些皮肤疾病在IBD患者中的流行率,特征和影响需要进一步阐明.
研究的目的:
- 确定CD和UC患者队列中的皮肤表现的患病率和类型.
- 调查皮肤病,IBD活动和治疗反应之间的关联.
主要方法:
- 分析了250名IBD患者 (140名CD,110名UC) 的队列.
- 收集的数据包括患者人口统计,疾病持续时间和皮肤形态.
- 评估皮肤问题的频率,与疾病活动的联系,以及对治疗的反应.
主要成果:
- 皮肤表现发生在31.2%的IBD患者中,CD中更常见 (35%) 比UC (26%).
- 最常见的是结节性红疹 (11.2%),皮质性性皮质 (5.6%),以及围皮肤标签 (8%).
- 活跃疾病与皮肤表现有显著的相关性 (45%与缓解中的18%相比). 与传统疗法 (36%) 相比,抗TNF治疗显示出较少的新皮肤问题 (20%),尽管在5%的生物使用者中发生了矛盾反应.
结论:
- 皮肤表现在IBD患者中很普遍,CD和UC之间的频率不同.
- 疾病活动与皮肤表现的发展密切相关.
- 抗TNF疗法可能会减少新的皮肤表现,但生物治疗可能会产生矛盾反应.
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